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Prepare an 8×8 or 9×9 baking dish by lining it with waxed paper.
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In a large microwave-safe bowl, add the butter and peanut butter. Heat in the microwave on high for 1 minute or until the butter has melted. Stir to combine.
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Add the marshmallow cream and powdered sugar to the peanut butter mixture, stirring until blended. The mixture will be very thick.
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Transfer the fudge into the prepared dish and smooth into an even layer.
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Refrigerate for at least 2 hours prior to slicing and serving.
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Store in an airtight container in the refrigerator for up to 2 weeks.